End Stage Renal Disease (ESRD)
Glomerular malfunction ▶ Retention of large, middle and small molecular Uremic toxins ▶ Systemic complications of uremia ▶ Poor life quality ▶ Renal replacement therapy
The combined hemodialysis/ hemoperfusion procedure (HD+HP) makes advantage of each other for blood purification, in this way, metabolic products and uremic toxins produced by renal failure patient could be thoroughly removed and the water, as well as electrolyte could be regulated to balance. Eventually, internal environment remains balance and patient’s life quality is improved.
Some Toxins of Uremia and Relevant Complications
Medium and Large Molecular Toxins | Protein Bound Toxins | ||
β2 Micoglobulin | Amyloidosis and Carpal Tunnel Syndrome | Advanced Glycation End Products | Amyloidosis and Atherosclerosis |
Renin, Angiotensin | Intractable Hypertension | Indoxyl Sulfate | Glomerulosclerosis |
Parathyroid Hormone | Renal Osteopathy, Ectopic Calcification | Glomerular Sclerosis | Cardiovascular Complications |
Oxidation Protein Products | Atherosclerosis | Leptin | Malnutrition |
Interleukin 1,6 | Micro Inflammatory | Cresol,Paracresol | Hepatotoxicity |
TNF-a Tumor Necrosis Factor TNF-a | Hippuric Acid | Insulin Resistance, Abnormal Glucose Tolerance |
Adsorption Sketch of MG Series Hemoperfusion Cartridge
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